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CNS stimulants, at recommended doses, may cause psychotic or manic symptoms (., hallucinations, delusional thinking, or mania) in patients without a prior history of psychotic illness or mania. If such symptoms occur, consider discontinuing QUILLIVANT XR. In a pooled analysis of multiple short-term, placebo-controlled studies of CNS stimulants, psychotic or manic symptoms occurred in approximately % of CNS stimulant-treated patients, compared to 0 in placebo-treated patients.

Dexmethylphenidate hydrochloride is a white to off white powder. Its solutions are acid to litmus . It is freely soluble in water and in methanol, soluble in alcohol, and slightly soluble in chloroform and in acetone.

It is generally agreed that acute episodes of MDD require several months or longer of sustained pharmacological therapy beyond response to the acute episode. Effexor XR/Effexor have demonstrated continuation of response in clinical studies up to 52 weeks, at the same dose at which patients responded during the initial treatment [ see Clinical Studies () ]. It is not known whether or not the dose of Effexor XR needed for maintenance treatment is identical to the dose needed to achieve an initial response. Patients should be periodically reassessed to determine the need for maintenance treatment and the appropriate dose for such treatment.


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